CSF monoamine metabolites in depression and schizophrenia

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Abstract
CSF concentrations of 5 monoamine metabolites before and after probenecid administration were studied in normal subjects and patients with depression and schizophrenia. No differences were found in baseline metabolite concentrations among the 3 groups. CSF metabolite and CSF probenecid concentrations were significantly correlated in depressed patients for all metabolites, and there was decreased postprobenecid accumulation of homovanillic acid in the CSF of depressed patients compared with schizophrenic patients and with normal subjects. A method for correcting for probenecid concentrations was proposed. Data from normal subjects should be of value for other investigators using the probenecid technique.