A Simple and Efficient Procedure for the Synthesis of Optically Active 4-Methoxy-α-Methylphenylethylamine from Tyrosine
- 1 June 1998
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 28 (11) , 1935-1945
- https://doi.org/10.1080/00397919808007167
Abstract
Optically active 4-methoxy-α-methylphenylethylamine (1), a useful chiral building block in medicinal chemistry, was synthesized from L- or D-tyrosine by using a simple and efficient procedure via one-pot zinc reduction of the corresponding O-tosylate (4) in the presence of H2O and NaI in pure form.Keywords
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