Particulate Component of the Plasma of Fowls with Avian Lymphomatosis.

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Abstract
A particulate material has been obtained from the plasma of chickens affected with the RPL 12 lymphoid tumor strain. Electron micrographs of the particles sedi-mented directly from plasma and of those in ultracentrifugal concentrates reveal spherical or spheroidal particles of sizes varying from 70 to 160 mμ in diameter and an average diameter of about 117 mμ. Particle counts on the individual plasmas of birds with advanced disease gave values of 1 × 107 to 160 × 107 particles per ml in contrast with the normal plasmas in which only occasional or no particles of this size range were observed. The findings with this form of the leukosis complex are remarkably similar to the results of analogous studies on erythromyeloblastic leucosis. The particles seen in the present work are interpreted, tentatively, as representing the virus of one form of avian lymphomatiosis.

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