Miltefosine (Impavido): the first oral treatment against leishmaniasis
- 26 September 2003
- journal article
- Published by Springer Nature in Medical Microbiology and Immunology
- Vol. 193 (4) , 173-180
- https://doi.org/10.1007/s00430-003-0201-2
Abstract
Miltefosine is a novel antileishmanial drug that has significant selectivity in both in vitro and in vivo models. Clinical efficacy was demonstrated for the treatment of visceral leishmaniasis with the advantage of oral administration over the currently recommended antileishmanial drugs that require parenteral administration. Miltefosine produces high cure rates also in patients resistant to the standard antimonial therapy.Keywords
This publication has 53 references indexed in Scilit:
- Oral miltefosine treatment in children with mild to moderate Indian visceral leishmaniasisThe Pediatric Infectious Disease Journal, 2003
- Miltefosine, an Oral Agent, for the Treatment of Indian Visceral LeishmaniasisNew England Journal of Medicine, 1999
- Miltefosine — The Long-Awaited Therapy for Visceral Leishmaniasis?New England Journal of Medicine, 1999
- LeishmaniasisJournal of the American Academy of Dermatology, 1996
- Immunochemotherapy for a Systemic Intracellular Infection: Accelerated Response Using Interferon- in Visceral LeishmaniasisThe Journal of Infectious Diseases, 1995
- Aminosidine and its combination with sodium stibogluconate in the treatment of diffuse cutaneous leishmaniasis caused by Leishmania aethiopicaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1994
- Treatment of visceral leishmaniasis (kala-azar) with aminosidine (= paromomycin)-antimonial combinations, a pilot study in Bihar, IndiaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1992
- A dose-finding study of miltefosine (hexadecylphosphocholine) in patients with metastatic solid tumoursZeitschrift für Krebsforschung und Klinische Onkologie, 1992
- Characterization of the antitumor activity of hexadecylphosphocholine (D 18506)European Journal of Cancer and Clinical Oncology, 1988
- Syntheses and antimicrobial activities of alkyl lysophospholipids.CHEMICAL & PHARMACEUTICAL BULLETIN, 1982