Synthesis of Substituted 3‐Hydroxy‐1H,5H‐pyrido[1,2‐a]‐benzimidazol‐1‐ones as Possible Antimicrobial and Antineoplastic Agents

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Abstract
Syntheses of the title compounds 3 as possible antimicrobial and antineoplastic agents were achieved by reacting the active malonates 1 with the benzimidazoles 2a,b. On the other hand, reaction of 1c,d with 2‐methylbenzimidazole (2c) yielded the imidazoquinolinones 4a,b. Four compounds in the series 3 displayed in vitro antibacterial and antifungal activities.