EVALUATION OF BARIUM AND GASTROGRAFIN AS CONTRAST MEDIA FOR THE DIAGNOSIS OF ESOPHAGEAL RUPTURES OR PERFORATIONS

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Abstract
In order to study the effects of the commonly employed contrast media in the mediastinum, various combinations of contrast media and flora were instilled in the mediastinum of 30 domestic cats. The animals were sacrificed at serial time intervals following the mediastinal injection. These data suggest that the water soluble contrast media cause no significant histologic reaction. Barium causes granuloma formation, but has no additional deleterious effect when mixed with normal human mouth bacterial flora of various concentrations. Because of its superior physical properties, it appears to be the contrast agent of choice in difficult clinical problems with regard to esophageal rupture or perforation.

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