Serotonin-Containing Neurons in Brain: Depression of Firing by Monoamine Oxidase Inhibitors
- 11 September 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3950) , 1100-1102
- https://doi.org/10.1126/science.169.3950.1100
Abstract
Monoamine oxidase inhibitors were administered to rats while the activities of single, serotonin-containing neurons of the midbrain raphe nuclei were being monitored with microelectrodes. All the inhibitors tested (pargyline, tranylcypromine, phenelzine, iproniazid) caused depression of raphe unit firing rate. The ability of monoamine oxidase inhibitors to depress raphe units was impaired by prior treatment with p-chlorophenylalanine, an inhibitor of serotonin synthesis.Keywords
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