Glucuronidation of Entacapone, Nitecapone, Tolcapone, and Some Other Nitrocatechols by Rat Liver Microsomes
- 1 January 1997
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 14 (10) , 1444-1448
- https://doi.org/10.1023/a:1012133008134
Abstract
Purpose. Nitrocatechol COMT inhibitors are a new class of bioactive compounds, for which glucuronidation is the most important metabolic pathway. The objective was to characterize the enzyme kinetics...Keywords
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