Rapid Cytoreduction in Acute Leukemia

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Abstract
A patient with acute myelogenous leukemia and symptoms of cerebral leukostasis failed to respond to initial chemotherapy. Reduction in blast count from 200,000/.mu.l to 40,000/.mu.l was accomplished over a 5-h period by leukapheresis using an intermittent flow cell separator, and symptomatic improvement was dramatic. The technique is simple and rapidly effective and may prove a useful adjunct in the treatment of patients with acute leukemia and high blast counts.