Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in southern chinese
Open Access
- 1 June 1992
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 35 (6) , 641-646
- https://doi.org/10.1002/art.1780350607
Abstract
Objective. To investigate the predisposing role of major histocompatibility complex (MHC) genes to systemic lupus erythematosus (SLE) in a Chinese population. Methods. Polymorphism in the HLA-DRB, DQB, complement component C4, and 21-hydroxylase genes was analyzed by restriction fragment length polymorphism analysis and oligonucleotide probing of in vitro-amplified DNA from 88 Chinese patients with SLE and 69 matched control subjects. Results. HLA-DRw15 and DQw1 were significantly more frequent in patients (corrected P < 0.006, relative risk 5.2), but none of the 9 sequence variants of DQw1 were increased. The C4A gene deletion usually associated with SLE in Caucasoid and black patients was absent from all Chinese subjects, but possession of other C4 deletions and of DRw15 conferred the greatest risk (relative risk = 8.3). Conclusion. Different MHC haplotypes predispose to lupus in Chinese than in other ethnic groups. Our data suggest that the susceptibility lies at, or telomeric to, the DR locus, and that DRw15 and C4 deletions may act synergistically in conferring disease susceptibility.Keywords
This publication has 15 references indexed in Scilit:
- Nomenclature for factors of the HLA system, 1990Immunogenetics, 1991
- HLA‐DRB AND DQB TYPING BY A COMBINATION OF SEROLOGY, RESTRICTION FRAGMENT LENGTH POLYMORPHISM ANALYSIS AND OLIGONUCLEOTIDE PROBINGInternational Journal of Immunogenetics, 1991
- Major histocompatibility complex genes and susceptibility to systemic lupus erythematosusArthritis & Rheumatism, 1990
- C4 null phenotypes among lupus erythematosus patients are predominantly the result of deletions covering C4 and closely linked 21-hydroxylase A genes.Journal of Medical Genetics, 1988
- A DNA-RFLP TYPING SYSTEM THAT POSITIVELY IDENTIFIES SEROLOGICALLY WELL-DEFINED AND ILL-DEFINED HLA-DR AND DQ ALLELES, INCLUDING DRw10Transplantation, 1988
- Deletion of C4A genes in patients with systemic lupus erythematosusArthritis & Rheumatism, 1987
- Polymorphism of the human complement C4 and steroid 21-hydroxylase genes. Restriction fragment length polymorphisms revealing structural deletions, homoduplications, and size variants.Journal of Clinical Investigation, 1986
- Relationship between C4 null genes, HLA-D region antigens, and genetic susceptibility to systemic lupus erythematosus in Caucasian and Black AmericansThe American Journal of Medicine, 1986
- Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.BMJ, 1983
- The 1982 revised criteria for the classification of systemic lupus erythematosusArthritis & Rheumatism, 1982