Spin trapping experiments on nadh analogues and the role of radicals in carbonyl reductions

Abstract
1 H N.m.r. and gas chromatographic analysis of the reactants and products show that the reaction of N-benzyl-1,4-dihydronicotinamide (NBDN), an analogue of NADH, with pyridine-2-carbaldehyde does not pass through a radical intermediate during either a thermal or a photolytic reaction; photolysis led to the removal of NBDN but not to the production of the reduced substrate and radicals detected with e.s.r. spectroscopy were shown to be artifacts.

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