The reactivity of silyl ethers to the Swern reagent
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 1221-1223
- https://doi.org/10.1039/p19870001221
Abstract
The activated Me2SO reagent [Me2SO–(COCl)2, ‘Swern reagent’] oxidises the trimethylsilyl ethers of primary and secondary alcohols directly to the corresponding carbonyl compound. Useful selectivity is possible where competing ether groups possess large differences of steric hindrance. Dimethyl-t-butylsilyl ethers are unaffected by this reagent.Keywords
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