Implantation and early pregnancy: Effect of single-dose, early luteal phase administration of mifepristone (RU486) on implantation stage endometrium in the rhesus monkey
Open Access
- 1 September 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 11 (9) , 2026-2035
- https://doi.org/10.1093/oxfordjournals.humrep.a019538
Abstract
The characteristics of implantation stage endometrium following a single-dose, early luteal phase application of mifeprlstone (RU486) in proven conception cycles has been examined in the rhesus monkey in an attempt to understand the physiological basis of the anti-implantation activity of the drug. Endometrial samples were collected from monkeys subjected to vehicle (group 1, n±14) and RU486 (2 mg/kg body weight; group 2, n±12) on day 2 after the presumed day of ovulation of successfully mated cycles. The average diameter of glands (P vW) factor with no change in vW factor-positive vessels, and the apparent increase in collagen IV immunostain in subepitheliai and perivascular basement membrane in Implantation stage endometrium after early luteal phase RU486 treatment in monkeys.Keywords
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