IMMUNOLOGICAL AND BIOCHEMICAL STUDIES ON SERUM HAPTOGLOBIN

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Abstract
Antibody to purified type 1-1 human serum haptoglobin was obtained in rabbits. Using this antiserum it was demonstrated that the antigenic determinants of the haptoglobin molecule reside in both [apha]- and [beta]-chains. No immunological difference between the normal [apha]1F- and [apha]1S-chains of haptoglobin was detected. A number of healthy individuals whose haptoglobin pattern appeared normal by starch gel electrophoresis possessed a haptoglobin which can be distinguished immunologically from the common haptoglobin types. These immunological atypical haptoglobins were observed in individuals of types 1-1, 2-1, and 2-2. Combined immunological and chemical studies of purified haptoglobin enabled the construction of a tentative model for the structure of human type 1-1 haptoglobin.