Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random-effects model
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Open Access
- 8 March 2010
- journal article
- research article
- Published by Springer Nature in BMC Medical Research Methodology
- Vol. 10 (1) , 18
- https://doi.org/10.1186/1471-2288-10-18
Abstract
Antibodies directed against haemagglutinin, measured by the haemagglutination inhibition (HI) assay are essential to protective immunity against influenza infection. An HI titre of 1:40 is generally accepted to correspond to a 50% reduction in the risk of contracting influenza in a susceptible population, but limited attempts have been made to further quantify the association between HI titre and protective efficacy.Keywords
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