INTRANSAL ADMINSTRATION OF NITROGLYCERINE ATTENUATES THE PRESSOR RESPONSIVE TO LARYNGOSCOPY AND INTUBATION OF THE TRACHEA

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Abstract
The intranasal administration of nitroglycerine (NTG) was undertaken in 35 adult female patients 1 min before the induction of anaesthesia. A control group consisting of 32 patients did not receive NTG. Systolic arterial pressure (SAP) and heart rate (HR) were recorded before the induction of anaesthesia and at 0,3, and 5 min after tracheal intubation. SAP did not increase significantly in the NTG group immediately after intubation, while significant decreases in SAP were observed at 3 and 5 min (P>0.005 and P<0.001 respectively). SAP did increase significantly in the control group. HR was increased in both groups immediately after intubation (P<0.001 and P<0.001 respectively). NTG administered intranasally is a safe, simple and effective method to attenuate the hypertensive response to laryngoscopy and tracheal intubation.

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