Study of the possible association of HLA class II, CD4, and CD3 polymorphisms with schizophrenia
- 15 December 1994
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 54 (4) , 372-377
- https://doi.org/10.1002/ajmg.1320540417
Abstract
In the present study the HLA‐DRB and DPB1 alleles as well as CD4 and CD3 polymorphisms were tested in 100 Belgian schizophrenic patients and 204 controls. Our results indicate a significant negative association of the DPB1 0101 allele with schizophrenia (relative risk [RR] = 0.27). Furthermore a significant positive and negative association could be noticed for the CD4 A4 allele and CD4 A7/A8 genotype, respectively (RR 1.79 and 0.47, respectively). These findings suggest that some contribution of HLA class II and CD4 genes to an autoimmune‐like pathogenesis in schizophrenia might exist.Keywords
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