THE EFFECT OF THE PITUITARY ADRENOCORTICOTROPIC HORMONE AND OF CORTICOSTERONE ACETATE ON INSULIN HYPOGLYCEMIA AND LIVER GLYCOGEN IN ADRENALECTOMIZED MICE

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Abstract
The adrenocorticotrophic factor of the ant. pituitary failed to produce an anti-insulin effect and to promote the deposition of liver glycogen in adrenalectomized mice. Adm. of corticosterone protected adrenalectomized mice against insulin hypoglycemia and increased the amt. of liver glycogen under the same exptl. conditions. These results confirmed the assumption that the anti-insulin effect of the ant. pituitary is produced by the adrenocorticotrophic factor and is mediated through the adrenal cortex.

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