DELAYED CUTANEOUS HYPERSENSITIVITY TO OXAZOLONE IN MICE WITH TUMORS

Google Scholar
  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (4) , 907-910
Abstract
A murine model of immune responsiveness was adapted to study anergic conditions associated with neoplasia. Marked anergy observed in mice bearing [mouse] L1210 leukemia and [mouse null lymphoid cell-like] P-388 lymphoma was contrasted to the minimal immune depression associated with [mouse] B-16 melanotic melanoma and [mouse] Sarcoma 180J. The ability of N,N-bis(2-chloroethyl)-N-nitrosourea chemotherapy to reduce tumor burden without prolonged suppression of delayed cutaneous hypersensitivity was compared to the profound suppression of the cutaneous response observed with Adriamycin cytoreductive therapy. The applications of this model are discussed in relation to tumor-associated anergy, new approaches to the evaluation of pharmaceuticals and studies of combined chemoimmunotherapy regimens.

This publication has 1 reference indexed in Scilit: