Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC–MS/MS analysis
- 1 May 2007
- journal article
- Published by Elsevier in Journal of Pharmaceutical and Biomedical Analysis
- Vol. 44 (1) , 211-223
- https://doi.org/10.1016/j.jpba.2007.02.034
Abstract
No abstract availableKeywords
This publication has 30 references indexed in Scilit:
- Enzyme Kinetics of Cytochrome P450-Mediated ReactionsCurrent Drug Metabolism, 2012
- FLUORESCENCE-BASED ASSAYS FOR SCREENING NINE CYTOCHROME P450 (P450) ACTIVITIES IN INTACT CELLS EXPRESSING INDIVIDUAL HUMAN P450 ENZYMESDrug Metabolism and Disposition, 2004
- High‐throughput cytochrome P450 inhibition assays by ultrafast gradient liquid chromatography with tandem mass spectrometry using monolithic columnsRapid Communications in Mass Spectrometry, 2003
- Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug InteractionsDrug Metabolism and Disposition, 2002
- Cytochrome P450 Fluorometric Substrates: Identification of Isoform-Selective Probes for Rat CYP2D2 and Human CYP3A4.Drug Metabolism and Disposition, 2002
- Validation of higher‐throughput high‐performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomesRapid Communications in Mass Spectrometry, 2000
- Drug-drug interactions of new active substances: mibefradil exampleEuropean Journal of Clinical Pharmacology, 1999
- Incidence of Adverse Drug Reactions in Hospitalized PatientsJAMA, 1998
- Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substratesRapid Communications in Mass Spectrometry, 1998
- P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclaturePharmacogenetics, 1996