Does massively parallel DNA resequencing signify the end of histopathology as we know it?
- 17 November 2009
- journal article
- review article
- Published by Wiley in The Journal of Pathology
- Vol. 220 (2) , 307-315
- https://doi.org/10.1002/path.2636
Abstract
Next‐generation DNA sequencing devices have revolutionized cancer genomics by bringing whole genome resequencing of patients' tumours within practical and economic reach. We present an overview of the techniques involved and review early results from the resequencing of cancer genomes. The possible impacts of whole‐genome and trancriptome resequencing in clinical cancer research and the practice of pathology are discussed. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.Keywords
This publication has 47 references indexed in Scilit:
- Accurate whole human genome sequencing using reversible terminator chemistryNature, 2008
- The diploid genome sequence of an Asian individualNature, 2008
- Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysNature, 2008
- Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem CellsCell, 2008
- Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencingNature Genetics, 2008
- The complete genome of an individual by massively parallel DNA sequencingNature, 2008
- The Catalogue of Somatic Mutations in Cancer (COSMIC)Current Protocols in Human Genetics, 2008
- Patterns of somatic mutation in human cancer genomesNature, 2007
- Gene expression profiling predicts clinical outcome of breast cancerNature, 2002