A gene producing symmelia in the mouse

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Abstract
The inheritance and description of a lethal condition involving sireniform abnormalities in mice are reported. Symmelia was produced by homozygosity for an incomplete recessive gene provisionally called siren (symbol srn). Sirens were apodal, monopodal, or dipodal. with the ischia present as a vestigial structure or missing. Femora, when present, were medially placed and usually fused. Pubes and tibiae were abnormal in some cases, and fibulae usually were. Visceral defects included absent or abnormal kidneys and adrenals, and blind or undeveloped intestines.