Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease
Top Cited Papers
Open Access
- 23 February 2000
- journal article
- clinical trial
- Published by American Medical Association (AMA) in JAMA
- Vol. 283 (8) , 1007-1015
- https://doi.org/10.1001/jama.283.8.1007
Abstract
Alzheimer disease (AD) affects more than 4 million Americans and is one of the most frequent obstacles to healthy aging in this country. Women appear to be at higher risk for developing AD, only in part due to increased longevity.1 Because women with AD also live longer than men with AD, there are approximately twice as many women as men in the population with this disorder. It has been suggested that the abrupt decline of estrogen production in postmenopausal women may be associated with a vulnerability of women to develop AD. Men, in contrast, have an intrinsic supply of estrogen by having the ability to aromatize testosterone into estrogen in the brain.Keywords
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