Large-scale structure of genomic methylation patterns
Open Access
- 19 December 2005
- journal article
- Published by Cold Spring Harbor Laboratory in Genome Research
- Vol. 16 (2) , 157-163
- https://doi.org/10.1101/gr.4362006
Abstract
The mammalian genome depends on patterns of methylated cytosines for normal function, but the relationship between genomic methylation patterns and the underlying sequence is unclear. We have characterized the methylation landscape of the human genome by global analysis of patterns of CpG depletion and by direct sequencing of 3073 unmethylated domains and 2565 methylated domains from human brain DNA. The genome was found to consist of short (8 bp do not methylate their DNA.Keywords
This publication has 35 references indexed in Scilit:
- Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cellsNature Genetics, 2005
- CpG Islands in vertebrate genomesPublished by Elsevier ,2004
- Efficient approximations for learning phylogenetic HMM models from dataBioinformatics, 2004
- BLAT—The BLAST-Like Alignment ToolGenome Research, 2002
- Genome-Wide Profiling of DNA Methylation Reveals Transposon Targets of CHROMOMETHYLASE3Current Biology, 2002
- Initial sequencing and analysis of the human genomeNature, 2001
- Thermodynamics of specific and non-specific DNA binding by the c-myb DNA-binding domainJournal of Molecular Biology, 1998
- Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityPublished by Elsevier ,1992
- DNA methylation affects the formation of active chromatinCell, 1986
- The somatic replication of DNA methylationCell, 1981