Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins
- 1 January 2007
- Vol. 93 (1) , 82-88
- https://doi.org/10.1136/hrt.2006.089359
Abstract
Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; pConclusion: Stretch is an important factor in the electrical activity of the pulmonary vein. Stretch-induced arrhythmogenic activity of the pulmonary vein may contribute to the genesis of atrial fibrillation.Keywords
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