Failure of Oral Activated Charcoal to Accelerate the Elimination of Amiodarone and Chloroquine

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Abstract
1 The effect of activated charcoal on the elimination of amiodarone and chloroquine was studied in the rat. 2 The study consisted of two separate experiments. Amiodarone and chloroquine were injected subcutaneously at doses of 200 mg kg-1 and 100 mg kg-1, respectively. Six rats in both experiments were put on a charcoal-containing diet 48 h after drug administration, while the control groups remained on a normal diet. 3 Treatment with repeated oral activated charcoal had no effect on the true elimination of amiodarone and chloroquine. 4 These results suggest that, after the distribution of amiodarone and chloroquine into peripheral compartments, their rate of elimination cannot be significantly accelerated with multiple oral doses of activated charcoal.

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