BIPHASIC EFFECTS OF META-CHLOROPHENYL-PIPERAZINE ON 3,4-DIHYDROXYPHENYLACETIC ACID CONCENTRATION IN RAT-BRAIN

  • 1 January 1977
    • journal article
    • letter
    • Vol. 17  (3) , 551-554
Abstract
M-Chlorophenyl-piperazine dihydrochloride injected i.p. into rats caused a rapid increase and a subsequent decrease in whole brain concentration of 3,4-dihydroxyphenylacetic acid (DOPAC), a metabolite of dopamine. The increase in DOPAC at 30 min and the decrease at 3 h were dose-related and occurred after doses as low as 5 mg/kg of m-chlorophenyl-piperazine dihydrochloride.

This publication has 1 reference indexed in Scilit: