IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
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Open Access
- 8 August 2005
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 202 (4) , 473-477
- https://doi.org/10.1084/jem.20050304
Abstract
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum immunoglobulin G autoantibody (NMO-IgG) serves as a specific marker for NMO. Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier. NMO may represent the first example of a novel class of autoimmune channelopathy.Keywords
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