Studies on the structure activity relationship of adrenergic .BETA.-mimetic benzylamine derivatives. II. 1-Alkylamino-2-phenyl-1,2,3,4-tetrahydronaphthalenes.

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Abstract
The synthesis and adrenergic activity of stereoisomeric 1-methylamino- and 1-isopropylamino-2-(3,4,5-trimethoxyphenyl)-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalenes, rigid structures related to the benzylamine derivatives, are presented. These compounds possess direct .beta.-stimulating activity both in the isolated tracheal and right atrial preparations of the guinea pigs. The structure-activity relationship in this series is described.

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