Glucocorticoid Induced Protection in Experimental Traumatic Shock

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Abstract
Methylprednisolone (45 mg/kg) given to rats subjected to drum trauma (LD85) significantly increased survival time from 2.4-4.5 h. Coincident with the prolonged survival was a higher mean arterial blood pressure. Methylprednisolone exerted no effect on blood pressure in nontraumatized control rats. Traumatic shock resulted in a 4-fold increase in circulating cathepsin D activity and a 3-fold increase in circulating MDF [myocardial depressant factor] activity. Methylprednisolone significantly (P < 0.01) prevented the increase in both substances. Methylprednisolone protects in traumatic shock by a mechanism involving lysosomal membrane stabilization rather than by an active hemodynamic action.

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