Immunology of Interferons

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Abstract
Rabbits immunized with protective interferons prepared in allogeneic RK 13 and SIRC cells failed to develop neutralizing antibodies against either, although parallel groups of animals responded well to repeated injections of xenogeneic interferon prepared in L cells, which is non-protective for the rabbit host. All interferons which were xenogeneic and non-protective for guinea pigs elicited antibodies in that species. Significant levels of neutralizing antibodies appeared also in rabbits following immunization with two protective interferons derived from xenogeneic (human) cells. Immunologic analysis of human interferons elicited in four different types of cells revealed that minor antigenic variations may be detectable by means of antibody neutralization assays.

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