Graft-versus-Host Disease after Intrauterine and Exchange Transfusions for Hemolytic Disease of the Newborn
- 14 February 1974
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 290 (7) , 359-363
- https://doi.org/10.1056/nejm197402142900703
Abstract
Fatal graft-versus-host disease developed in two immunologically normal infants after intrauterine and exchange transfusions for Rh-incompatible hemolytic disease of the newborn. In both cases, the diagnosis of graft-versus-host disease was established by the clinical and pathological features of the disease and the presence of lymphoid chimerism. The origin of the lymphocytes causing the graft-versus-host disease was demonstrated by karyotype analysis to be an exchange-transfusion donor in both cases. (N Engl J Med 290:359–363, 1974)Keywords
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