Studies on ovarian prostaglandin production in relation to ovulation in the rat

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Abstract
Prostaglandin (PG) and thromboxane (TX) synthesizing capacities of the rat ovary were measured at 4-h intervals during 4-day estrous cycle of the rat. Production of PGE-2, PGF-2.alpha., 6-oxo-PGF-1.alpha. and TXB-2 increased 5-fold, 1.6-fold, 1.7-fold and 1.7-fold, respectively, between 1800 h on the day of pro-estrus and 0200 h at estrus. This preferential stimulation of ovarian PGE-2 production, after the ovulatory surge of LH [luteinizing hormone] before ovulation, provides further evidence for the involvement of ovarian PGE-2 in ovulation in the rat. These increases in ovarian PG production were not due to differences in arachidonic acid availability, PG metabolism, or the interconversion of PGE-2 and PGF-2.alpha.. The greater stimulation of PGE-2 synthesis was not due to an increase in PGH-2 to PGE-2 synthetase activity. The ovulatory LH surge late in the afternoon of pro-estrus in the rat causes an increase in ovarian cyclo-oxygenase (PGH-2 synthetase) activity with the majority of the PGH-2 synthesized being directed into the PGE-2-forming pathway.

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