Structure and Polymorphism of the UL6 Portal Protein of Herpes Simplex Virus Type 1
Open Access
- 15 November 2004
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (22) , 12668-12671
- https://doi.org/10.1128/jvi.78.22.12668-12671.2004
Abstract
By electron microscopy and image analysis, we find that baculovirus-expressed UL6 is polymorphic, consisting of rings of 11-, 12-, 13-, and 14-fold symmetry. The 12-mer is likely to be the oligomer incorporated into procapsids: at a resolution of 16 Å, it has an axial channel, peripheral flanges, and fits snugly into a vacant vertex site. Its architecture resembles those of bacteriophage portal/connector proteins.Keywords
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