SEQUENCES HOMOLOGOUS TO THE HUMAN D1S1 LOCUS PRESENT ON HUMAN CHROMOSOME-3
- 1 April 1986
- journal article
- research article
- Vol. 38 (4) , 428-436
Abstract
We have investigated the segregation, in somatic cell hybrids, of the human D1S1 locus, previously assigned to 1p36 by in situ hybridization. We have shown that the clone which defines this locus, .lambda.Ch4A-H3, originates from human chromosome 3, but contains a 1.7-kilobase (kb) PstI-HindIII repetitive element that is also present on chromosome 1, probably distal in PGD. The clone recognizes restriction fragment length polymorphisms within the single-copy sequence on chromosome 3 and one for the enzyme StuI in the repeated sequence on chromosome 1. These experiments thus expose a level of complexity in the D1S1 locus not revealed by earlier in situ hybridization studies.This publication has 15 references indexed in Scilit:
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