Distribution of Uric Acid in Rat Tissues and Its Production in Tissue Homogenates

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Abstract
Tissues from 66 albino rats in 22 expts. were analyzed for uric acid (extractable with Li2CO3 soln.) after preservation with ice-salt mixture, granular CO2 ice, and granular CO2 ice plus the xanthine oxidase inhibitor 2-amino-4-hydroxy-6-formylpteridine, respectively. Differences in the content of soluble urate in those tissues and organs examined became almost negligible as more effective precautions were taken to prevent post-mortem changes suggesting that all tissues of this animal contain about the same concn. of urate; that is, 4-6 mg./100g./ wet wt. of tissue. When tissue homogenates were incubated aerobically or anaerobically, testicle, lung, spleen, and kidney cortex and medulla were found capable of increasing substantially their soluble urate content, while brain and muscle were not.

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