Blood flow in nasal polyps

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Abstract
The etiology of the nasal polyps is still unknown and there is no agreement on the mechanism of polyp development. Among many theories on polyp formation, changes in the vascularity of the mucous membrane have been discussed. Extensive histological and biochemical studies of nasal polyps have been made but only very few physiological studies have been made concerning the blood flow. Such studies may shed some light on the pathogenesis of nasal polyps. In the present work the 133Xe wash-out method was used to determine the blood flow in nasal polyps. The disappearance of 133Xe from the nasal mucosa depends mainly on the nasal blood flow. A small part of the 133Xe (about 5%) disappears by leakage through the mucosa to the nasal air and thus constitutes a source of error. This might be more pronounced when calculating the blood flow in a nasal polyp than in the mucosa itself, since the polyp has a relatively larger surface in contact with the air in the nasal cavity.

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