QUINIDINE HEPATOTOXICITY - REPORT OF A CASE AND REVIEW OF LITERATURE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 70  (6) , 1136-1140
Abstract
A case is described of presumed quinidine hepatotoxicity, characterized by the development of fever, abnormal serum transaminase values, which improved after cessation of the drug but recurred after a challenge dose, and centrizonal hepatocellular necrosis detected on liver biopsy. Morphological changes on EM, consistent with a drug reaction, are also described. Pertinent features of previous case reports are analyzed, and the histological findings by light microscopy of the present and past cases are discussed. The development of unexplained fever within 1 mo. of quinidine administration should lead to consideration of possible hepatotoxicity.

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