The fractional distribution of the cardiac output in man using microspheres labelled with technetium 99m

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Abstract
To investigate the distribution of organ blood flow in patients we have developed a method of quantitating the whole-body fractional distribution of 99Tcm-labelled microspheres. The microspheres were injected into the left ventricle in nine patients with normal cardiac indices (> 3 1/min/m2; Group A) and 11 patients with low cardiac indices (< 2.5 1/min/m2; Group B). The fractional organ content of the total injected dose was estimated following correction for geometry and transmission using a gamma camera. Cerebral blood flow was 579 ±163 ml/min (x ± SD) in Group A and 593 ± 158 ml/min in Group B (p not significant (NS)). Myocardial flow in Group A was 266± 82 ml/min and in Group B was 237 ± 57 ml/min (p, NS). Total renal blood flow was 749 ± 161 ml/min in Group A and 614 ± 181 ml/min in Group B (p < 0.01). There was a negative correlation between cardiac index and the percentage of the cardiac output distributed to brain (r =−0.70,p < 0.01), heart (r = −0.67, p <0.01) and kidneys (r = −0.47), p...