BILIARY RESPONSE TO FOOD IN RABBITS: ROLE OF THE GALL BLADDER AND THE ENTEROHEPATIC CIRCULATION OF BILE SALTS

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Abstract
The biliary response to feeding was investigated in intact and cholecystectomized rabbits, with and without interruption of the enterohepatic circulation of bile salts. The relative contribution of the different secretory mechanisms involved in this process was examined. Feeding induced an increase in the flow and HCO3- concentration of the bile and a slight decrease in the bile salt content in rabbits with gall bladders and the enterohepatic circulation intact. Feeding with the enterohepatic circulation interrupted elicited a drop in bile flow and the bile salt concentration, but an increase in HCO3- concentration. Interruption of the enterohepatic circulation dramatically modifies the feeding response: a response to food is still detectable after interruption, but is masked by the negative effects of drainage of the bile away from the duodenum.

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