DEFICIENCY OF CATALYTIC IRON IN THE BRAIN IN SCHIZOPHRENIA

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Abstract
The histologic approach to schizophrenia has failed. This was brought out forcibly in 1925 by Dunlap,1 who concluded that the changes described in the literature were not characteristic, and that identical changes might be found in the brains of mentally normal persons killed by accident. The past four years have brought forward nothing of consequence to enlighten the situation, although contributions have been numerous and at least one synthetic review has been offered.2 This does not mean that there is no histologic alteration in the brain of the schizophrenic person. It indicates merely that, with the methods so far applied and the controls so far run, significant changes have not been detected. It is a criticism rather of our methods than of our eyes. By the application of already known methods to the chemistry of the cell, however, there is opened a different approach that may lead to

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