Homovanillic acid in rat caudate and prefrontal cortex following phencyclidine and amphetamine
- 1 September 1984
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 84 (1) , 136-137
- https://doi.org/10.1007/bf00432043
Abstract
Phencyclidine (PCP) and d-amphetamine (AMP) had different effects upon homovanillic acid (HVA) levels in rat prefrontal cortex as compared to caudate. Lower doses of PCP increased HVA in prefrontal cortex only while lower doses of AMP decreased HVA in caudate alone. Higher doses of both drugs produced a decreased HVA in caudate and an increase in prefrontal cortex. At some doses PCP may selectively activate mesocortical dopaminergic neurons.Keywords
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