Natural and Acquired Resistance of Klebsiella-Aerobacter to Cephalothin and Cephaloridine.

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Abstract
Summary Of 161 recently isolated Klebsiella-Aerobacter strains, nearly all motile strains (Aerobacter) were highly resistant to cephalothin and cephaloridine, but susceptible to tetracycline, chloramphenicol, streptomycin, kanamycin, furadantin, and the sulfonamides. In contrast, all non-motile strains (Klebsiella) were susceptible to both cephalothin and cephaloridine, more so to the former, but were frequently resistant to several of the other 6 drugs. MIC tests with Klebsiella strains frequently demonstrated inconsistent end points with one or more clear tubes occurring between tubes showing growth. This "skipped tube" phenomenon suggested rapidly acquired resistance to these cephalosporin derivatives. The rapid in vitro development of a high degree of resistance by serial transfer of the organisms in these antibiotics further suggests that clinically resistant infections by these organisms may occur with unusual frequency.

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