RE-ELEVATION OF GAMMA-GLUTAMYL-TRANSFERASE TRANSPEPTIDASE ACTIVITY IN PERIPORTAL HEPATOCYTES OF RATS WITH AGE
- 1 January 1980
- journal article
- research article
- Vol. 71 (3) , 362-366
Abstract
Changes in the level of .gamma.-glutamyl transpeptidase (.gamma.-GTP) in the rat liver with age were studied histochemically and biochemically. A high enzyme activity was seen throughout the hepatic lobule with some predominance in the periportal area in the neonatal rat liver. This enzyme activity disappeared almost completely from the hepatocytes of young adults. However, after 30 wk of age, there was a gradual re-elevation of the enzyme activity in the periportal hepatocytes, attaining a level similar to that of neonatal liver. Expression of .gamma.-GTP activity in the rat hepatocytes is associated with not only onconeonatal events but also aging. [The importance of .gamma. GTP metabolism in hepatocarcinogenesis is stressed.].This publication has 2 references indexed in Scilit:
- QUANTITATIVE HISTOCHEMICAL AND AUTORADIOGRAPHIC STUDIES OF HEPATOCARCINOGENESIS IN RATS FED 2-ACETYLAMINOFLUORENE FOLLOWED BY PHENOBARBITAL1978
- HISTOCHEMICAL DEMONSTRATION OF INCREASED ACTIVITY OF γ-GLUTAMYL TRANSPEPTIDASE IN RAT LIVER DURING HEPATOCARCINOGENESISACTA HISTOCHEMICA ET CYTOCHEMICA, 1976