Calcium dependence of glutamate receptorevoked alkaline shifts in hippocampus
- 1 December 1994
- journal article
- synaptic transmission
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 5 (18) , 2441-2445
- https://doi.org/10.1097/00001756-199412000-00009
Abstract
GLUTAMATE receptor activation induces an extracellular alkalinization in rodent hippocampus. We studied its Ca2+ dependence and pharmacology in hippocampal slices. Glutamate-evoked alkaline shirts were blocked by 0 Ca2+ saline. Alkalinizations Induced by AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) and NMDA (N-methyl-D-aspartate) were abolished by 20 μuM CNQX (6-cyano-7-nitro-nitroquinoxaline-2,3-dione) and 50 μM APV (DL-2-amino-5-phosphonovalerate), respectively. The AMPA- and NMDA-evoked alkaline shifts were blocked by 0 Ca2+, however, AMPA-induced [K+]0, elevation was unaffected. These data suggest that the glutamate receptor-channel does not mediate H+ influx, and support a role for Ca2+-H+ exchange.Keywords
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