6,7-Dihydroxyflavone Dramatically Intensifies the Susceptibility of Methicillin-Resistant or -Sensitive Staphylococcus aureus to β-Lactams
Open Access
- 1 April 2004
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (4) , 1357-1360
- https://doi.org/10.1128/aac.48.4.1357-1360.2004
Abstract
We have demonstrated that 6,7-dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA) but that at concentrations less than MIC it synergistically elevates the susceptibility of clinically isolated MRSA and methicillin-sensitive S. aureus strains to β-lactam antibiotics from 8- to 32,800-fold.Keywords
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