A New, Rapid Gas Chromatography Method for the Detection of Basic Drugs in Postmortem Blood, Using a Nitrogen Phosphorus Detector. Part I. Qualitative Analysis
- 1 January 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 2 (1) , 26-31
- https://doi.org/10.1093/jat/2.1.26
Abstract
A new, rapid blood screening method is presented for the detection of basic drugs such as phenothiazines, tricyclic antidepressants, antihistamines, analgesics, and other drug classes of toxicological interest. The method involves a one-step extraction from 1.0 ml of postmortem blood buffered to pH 9.0–9.5 into n-butyl chloride. No back extraction or clean-up steps are required. Extracts are injected on 3% OV-1 and 3% OV-17 columns coupled to nitrogen phosphorus (NP) detectors. Sensitivity limits are drug-dependent and range from 200–500 ng/ml for the various drugs listed in the report.This publication has 1 reference indexed in Scilit:
- Determination of propoxyphene in human plasma by gas chromatographyAnalytical Chemistry, 1968