Non-A, non-B hepatitis: visualization of virus-like particles from chimpanzee and human sera

1 September 1989

journal article
research article
Published by Springer Nature in Archiv für die gesamte Virusforschung

Vol. 104 (3-4) , 351-355
https://doi.org/10.1007/bf01315557

Abstract

Virus-like particles (VLP), morphologically similar to togavirus particles, were detected in the sera of chimpanzees and humans with chronic non-A, non-B (NANB) hepatitis. Particles resembling the virus were also found in the cytoplasm of hepatocytes obtained from NANB hepatits infected chimpanzees. Furthermore, two chimpanzees inoculated with materials containing the VLP developed NANB hepatitis. These results strongly suggest that the VLP may be closely associated with the agent of NANB hepatitis.

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