Abstract
A study has been made of the modifications of the shape of a nerve action potential dependent upon the placement of the two electrodes, always necessary for a lead. In a classic diphasic lead separation of the electrodes brings out, in addition to a separation of the phases, the appearance of a positive deflection traceable to the passage of an impulse between the electrodes. This phenomenon, called the lead separation effect (1.s.e.), must be considered as an expression of a feature of normal nerve fiber biophysics. It regularly appears and it can be analyzed with respect to the position of the sink maximum. Also it cannot be eliminated by a block at the second electrode.

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