Soluble IL-2 receptors in acute and subacute encephalitis

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Abstract
Elevated levels of soluble interleukin-2 receptors were present in the serum from patients with acute primary and postinfectious encephalitis and subacute sclerosing panencephalitis. In addition, soluble interleukin-2 receptors were detected in the cerebrospinal fluid from patients with acute primary encephalitis. Their presence in the cerebrospinal fluid was not explained by damage to the blood—brain barrier and our data attest to their local origin. This suggests that it may be possible in certain neurological diseases to detect cerebral Tlymphocyte activation through a specific marker in the cerebrospinal fluid.